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For instance, the FXR agonist obeticholic acid (OCA) has been demonstrated to attenuate systemic inflammation by inhibiting the NF-B signaling pathway, while TGR5 activation similarly suppresses macrophage inflammatory responses 164,165,166

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Suitable water soluble preservatives which are employed in the drug delivery vehicle are sodium bisulfate, sodium thiosulfate, potassium thiosulfate, ascorbate, benzalkonium chloride, chlorobutanol, thimerosal, parabens, benzyl alcohol, phenylethanol and others

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